Reported herein is a photochemical strategy for C(sp3)-H azolation of ethers via a hydrogen-atom transfer and radical-polar crossover process, offering efficient access to valuable N-alkylated azoles under visible-light irradiation. The… Click to show full abstract
Reported herein is a photochemical strategy for C(sp3)-H azolation of ethers via a hydrogen-atom transfer and radical-polar crossover process, offering efficient access to valuable N-alkylated azoles under visible-light irradiation. The protocol is metal-free and photocatalyst-free, and exhibits good to excellent yields and broad substrate scope with regard to azoles. EPR experiments provide evidence for the formation of intermediates formed in situ.
Keywords:
polar crossover;
visible light;
radical polar;
azolation ethers;
ethers via;
sp3 azolation
Journal Title: Chemical communications
Year Published: 2024
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Journal Title: Chemical communications
Year Published: 2024
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!