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Ring expansion/ opening reactions of epoxy ene-amides: Access to azabicyclononene, tetrahydropyridine and tetrazole scaffolds

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Ene-sulfonamides, obtained from epoxy (terminal as well as internal) benzenesulfonamide and substituted chloro-acrylaldehydes, undergo Lewis acid (BF3.OEt2) catalysed cyclisation to afford azabicyclononene, tetrahydropyridinyl benzoate or tetrahydropyridine-carbaldehyde scaffolds depending on the... Click to show full abstract

Ene-sulfonamides, obtained from epoxy (terminal as well as internal) benzenesulfonamide and substituted chloro-acrylaldehydes, undergo Lewis acid (BF3.OEt2) catalysed cyclisation to afford azabicyclononene, tetrahydropyridinyl benzoate or tetrahydropyridine-carbaldehyde scaffolds depending on the...

Keywords: ene; opening reactions; epoxy ene; expansion opening; reactions epoxy; ring expansion

Journal Title: New Journal of Chemistry
Year Published: 2023

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