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Diterpenoids with novel 6/5-5 spiro tricyclic skeleton from Orthosiphon wulfenioides and their NLRP3 inflammasome inhibitory activity

Wulfenioidins A−C (1−3) with an unprecedented 6/5−5 tricyclic skeleton featuring unusual spiro [4.4] nonane were isolated from the whole plant of Orthosiphon wulfenioides. Their structures were elucidated by X-ray diffraction,... Click to show full abstract

Wulfenioidins A−C (1−3) with an unprecedented 6/5−5 tricyclic skeleton featuring unusual spiro [4.4] nonane were isolated from the whole plant of Orthosiphon wulfenioides. Their structures were elucidated by X-ray diffraction,...

Keywords: novel spiro; tricyclic skeleton; orthosiphon wulfenioides; diterpenoids novel

Journal Title: Organic Chemistry Frontiers
Year Published: 2023

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