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Metal-free 1,3-dipolar cyclization of azides with HFO-1233zd(E) under amine participation: one-step regioselective synthesis of 1-N-substituted 1,2,3-triazole-4-carboxamide derivatives

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A simple and metal-free strategy for regioselective synthesis of 1-N-substituted 1,2,3-triazole-4-carboxamide derivatives was developed by employing azides, HFO-1233zd (E) and amines in aqueous reaction medium. The defluorination functionalization of the... Click to show full abstract

A simple and metal-free strategy for regioselective synthesis of 1-N-substituted 1,2,3-triazole-4-carboxamide derivatives was developed by employing azides, HFO-1233zd (E) and amines in aqueous reaction medium. The defluorination functionalization of the...

Keywords: triazole carboxamide; substituted triazole; metal free; synthesis substituted; regioselective synthesis; carboxamide derivatives

Journal Title: Organic Chemistry Frontiers
Year Published: 2023

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