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HFIP-promoted para-selective alkylation of anilines and phenols with tertiary alkyl bromides

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A Hexafluoroisopropanol-promoted highly regioselective Friedel-Crafts alkylation of arenes has been developed in this study. Various arenes, including anilides, anisoles, and phenols, were compatible with the reaction, leading to the para-alkylated... Click to show full abstract

A Hexafluoroisopropanol-promoted highly regioselective Friedel-Crafts alkylation of arenes has been developed in this study. Various arenes, including anilides, anisoles, and phenols, were compatible with the reaction, leading to the para-alkylated...

Keywords: alkylation anilines; para selective; alkylation; hfip promoted; promoted para; selective alkylation

Journal Title: Organic Chemistry Frontiers
Year Published: 2023

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