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An enantioselective construction of spirocyclic ketones featuring stereogenetic carbon centers bearing the gem-difluoromethylene group has been accomplished through N-heterocyclic carbene (NHC)-catalyzed umpolung [3+2] annulation of enals with cyclic gem-difluoroalkyl ketones.... Click to show full abstract
An enantioselective construction of spirocyclic ketones featuring stereogenetic carbon centers bearing the gem-difluoromethylene group has been accomplished through N-heterocyclic carbene (NHC)-catalyzed umpolung [3+2] annulation of enals with cyclic gem-difluoroalkyl ketones....
Keywords:
bearing gem;
gem;
spirocyclic ketones;
carbene catalyzed;
catalyzed enantioselective;
heterocyclic carbene
Journal Title: Organic Chemistry Frontiers
Year Published: 2023
Link to full text (if available)
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Journal Title: Organic Chemistry Frontiers
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!