A variety of enantioenriched spirofuro[2,3-b]azepine-5,3’-indoline derivatives (dr > 20:1, up to 96% ee) were facilely synthesized through cycloisomerization/asymmetric formal [4+3] cycloaddition reactions of enyne-amides with isatin-derived enals under gold(I)/chiral N-heterocyclic... Click to show full abstract
A variety of enantioenriched spirofuro[2,3-b]azepine-5,3’-indoline derivatives (dr > 20:1, up to 96% ee) were facilely synthesized through cycloisomerization/asymmetric formal [4+3] cycloaddition reactions of enyne-amides with isatin-derived enals under gold(I)/chiral N-heterocyclic...
Keywords:
spirofuro azepine;
cycloisomerization;
azepine indoline;
indoline derivatives;
asymmetric synthesis
Journal Title: Organic Chemistry Frontiers
Year Published: 2023
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Journal Title: Organic Chemistry Frontiers
Year Published: 2023
Link to full text (if available)
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recommendations!