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Synthesis of 2-Pyrrolidinone Derivatives via N-Heterocyclic Carbene Catalyzed Radical Tandem Cyclization/Coupling Reaction

Herein, a practical, convenient and facile protocol to construct highly functionalized 2-pyrrolidinone enabled by N-Heterocyclic Carbene(NHC)-catalyzed radical tandem cyclization has been developed (30 examples, up to 94% yield). This method... Click to show full abstract

Herein, a practical, convenient and facile protocol to construct highly functionalized 2-pyrrolidinone enabled by N-Heterocyclic Carbene(NHC)-catalyzed radical tandem cyclization has been developed (30 examples, up to 94% yield). This method...

Keywords: radical tandem; catalyzed radical; tandem cyclization; pyrrolidinone; heterocyclic carbene

Journal Title: Organic Chemistry Frontiers
Year Published: 2023

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