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Visible-Light-Mediated C− F Bond Cleavage for the Synthesis of Polyfluorinated Compounds

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Herein, we describe a novel and efficient photo-redox catalytic difluorinated ester radical addition/defluoroalkylation coupling reaction between trifluoroacetic acid derivatives and α-trifluoromethyl alkenes. A series of polyfluorinated compounds were synthesized by... Click to show full abstract

Herein, we describe a novel and efficient photo-redox catalytic difluorinated ester radical addition/defluoroalkylation coupling reaction between trifluoroacetic acid derivatives and α-trifluoromethyl alkenes. A series of polyfluorinated compounds were synthesized by...

Keywords: mediated bond; bond cleavage; polyfluorinated compounds; visible light; cleavage synthesis; light mediated

Journal Title: Organic Chemistry Frontiers
Year Published: 2023

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