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Asymmetric binary-acid catalysis: a diastereo- and enantioselective oxa-Nazarov cyclization-Michael addition of conjugated 1,2-diketones

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Diastereo- and enantioselective oxa-Nazarov cyclization-Michael addition of conjugated 1,2-diketones was achieved by using an asymmetric binary-acid catalysis with chiral phosphoric acid and FeBr3. The reaction affords the corresponding chiral 3(2H)-furanones... Click to show full abstract

Diastereo- and enantioselective oxa-Nazarov cyclization-Michael addition of conjugated 1,2-diketones was achieved by using an asymmetric binary-acid catalysis with chiral phosphoric acid and FeBr3. The reaction affords the corresponding chiral 3(2H)-furanones...

Keywords: nazarov cyclization; enantioselective oxa; diastereo enantioselective; oxa nazarov; acid; cyclization michael

Journal Title: Organic Chemistry Frontiers
Year Published: 2023

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