LAUSR

Novel, stable silicon–pentafluoropropane compounds have been synthesised from the direct reaction of hydrofluorocarbons Z-CFH CFCF3 (Z-HFC-1225ye) with nBuLi, followed by appropriate silicon-halide. The compounds have been characterized by multinuclear NMR studies (19F, 1H, 29Si and 13C), DFT studies and structural confirmation was obtained by X-ray diffraction. Based on the outcome of treating synthetic silicon–pentafluoropropene compounds with different nucleophilic sources (nBuLi, tBuLi, MeLi, and PhLi) and computed for this reaction DFT energetics, it is clear that the C–Ftrans bond is more active than C–Fgem (Fgem and Ftrans are labelled with respect to Si). This provides a route for efficient modification of pentafluoropropene group, that can be a crucial step in developing pharmaceuticals that include propenyl or vinyl groups, addressing the demand for medicines based on long carbonic chains.