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Technology for generating especially important amide and peptide bonds from carboxylic acids and amines that avoids traditional coupling reagents is described. The 1-pot processes developed rely on thioester formation, neat,… Click to show full abstract
Technology for generating especially important amide and peptide bonds from carboxylic acids and amines that avoids traditional coupling reagents is described. The 1-pot processes developed rely on thioester formation, neat, using a simple dithiocarbamate, and are safe and green, and rely on Nature-inspired thioesters that are then converted to the targeted functionality.
Keywords:
amide peptide;
coupling reagents;
peptide bonds;
bonds carboxylic;
traditional coupling;
carboxylic acids
Journal Title: Chemical Science
Year Published: 2023
Link to full text (if available)
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Journal Title: Chemical Science
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!