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Targeted Proximity-Labelling of Protein Tyrosines via Flavin-Dependent Photoredox Catalysis with Mechanistic Evidence for a Radical-Radical Recombination Pathway

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Flavin-based photocatalysts such as riboflavin tetraacetate (RFT) serve as a robust platform for light-mediated protein labelling via phenoxy radical-mediated tyrosine-biotin phenol coupling on live cells. To gain insight into this... Click to show full abstract

Flavin-based photocatalysts such as riboflavin tetraacetate (RFT) serve as a robust platform for light-mediated protein labelling via phenoxy radical-mediated tyrosine-biotin phenol coupling on live cells. To gain insight into this...

Keywords: proximity labelling; protein tyrosines; via flavin; tyrosines via; labelling protein; targeted proximity

Journal Title: Chemical Science
Year Published: 2023

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