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Lewis acid-catalyzed diastereoselective carbofunctionalization of bicyclobutanes employing naphthols

Traditional radical-mediated ring-opening of bicyclo[1.1.0]butanes (BCBs) for cyclobutane synthesis suffers from poor diastereoselectivity. Although few reports on BCB ring-opening via polar mechanisms are available, the Lewis acid-catalyzed diastereoselective ring-opening of... Click to show full abstract

Traditional radical-mediated ring-opening of bicyclo[1.1.0]butanes (BCBs) for cyclobutane synthesis suffers from poor diastereoselectivity. Although few reports on BCB ring-opening via polar mechanisms are available, the Lewis acid-catalyzed diastereoselective ring-opening of...

Keywords: diastereoselective carbofunctionalization; carbofunctionalization bicyclobutanes; catalyzed diastereoselective; lewis acid; acid catalyzed; ring opening

Journal Title: Chemical Science
Year Published: 2023

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