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Tracking the mechanism of covalent molecular glue stabilization using native mass spectrometry

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Molecular glues are powerful tools for the control of protein-protein interactions. Yet, the mechanisms underlying multi-component protein complex formation remain poorly understood. Native mass spectrometry (MS) detects multiple protein species... Click to show full abstract

Molecular glues are powerful tools for the control of protein-protein interactions. Yet, the mechanisms underlying multi-component protein complex formation remain poorly understood. Native mass spectrometry (MS) detects multiple protein species...

Keywords: mass spectrometry; tracking mechanism; mechanism covalent; native mass

Journal Title: Chemical Science
Year Published: 2023

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