Substrate-controlled product divergence in the reaction of 2-aminopyrimidines with polyfluoroarenes under palladium catalysis is demonstrated for the first time. The reaction of secondary N-alkylpyrimidine-2-amines with polyfluoroarenes leads to C5-H polyfluoroarylation… Click to show full abstract
Substrate-controlled product divergence in the reaction of 2-aminopyrimidines with polyfluoroarenes under palladium catalysis is demonstrated for the first time. The reaction of secondary N-alkylpyrimidine-2-amines with polyfluoroarenes leads to C5-H polyfluoroarylation via C-H/C-H coupling, while secondary N-aryl substituents yield N-H polyfluoroarylation, forming triarylamines.
Keywords:
controlled divergent;
substrate controlled;
divergent remote;
aminopyrimidines polyfluoroarenes;
polyfluoroarylation;
catalysis
Journal Title: Chemical communications
Year Published: 2024
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!
Journal Title: Chemical communications
Year Published: 2024
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!