A one-step, on-tissue chemical derivatisation method for MALDI mass spectrometry imaging was found to improve the detectability of aldehydes and ketones by charge-tagging. The developed reactive matrices, containing a UV-chromophore,… Click to show full abstract
A one-step, on-tissue chemical derivatisation method for MALDI mass spectrometry imaging was found to improve the detectability of aldehydes and ketones by charge-tagging. The developed reactive matrices, containing a UV-chromophore, ionisable moiety and hydrazide group, showed an equal or higher detection efficiency than Girard's reagent P, enabling improved imaging of brain metabolites without the need for additional co-matrices.
Keywords:
mass spectrometry;
spectrometry imaging;
reactive matrices;
aldehydes ketones;
maldi mass
Journal Title: Chemical communications
Year Published: 2024
Link to full text (if available)
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Journal Title: Chemical communications
Year Published: 2024
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!