A protein trans-splicing (PTS)-based method for screening the peptides capable of binding to a target protein was developed using an engineered split intein and an aminoglycoside phosphotransferase. Two peptides selected… Click to show full abstract
A protein trans-splicing (PTS)-based method for screening the peptides capable of binding to a target protein was developed using an engineered split intein and an aminoglycoside phosphotransferase. Two peptides selected against MDM2 bind to MDM2 with high affinity and a peptide can induce apoptosis in SJSA-1 cells.
Keywords:
intein aminoglycoside;
using engineered;
mdm2;
split intein;
aminoglycoside phosphotransferase;
engineered split
Journal Title: Chemical communications
Year Published: 2025
Link to full text (if available)
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Journal Title: Chemical communications
Year Published: 2025
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!