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Biocatalytic Asymmetric Ring-Opening of meso-Epoxides to Enantiopure Cyclic trans-β-Amino Alcohols Involving a Key Amine Transaminase

Chiral cyclic β-amino alcohols are vital building blocks for the synthesis of numerous pharmaceuticals and bioactive molecules. Asymmetric ring-opening of cyclic meso-epoxides is a straightforward and appealing method for their... Click to show full abstract

Chiral cyclic β-amino alcohols are vital building blocks for the synthesis of numerous pharmaceuticals and bioactive molecules. Asymmetric ring-opening of cyclic meso-epoxides is a straightforward and appealing method for their...

Keywords: biocatalytic asymmetric; asymmetric ring; amino alcohols; ring opening; meso epoxides

Journal Title: Green Chemistry
Year Published: 2024

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