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Syntheses of highly functionalized cyclobutenes via [2+1+1] cycloaddition of isocyanides and an unprecedented ring expansion

A new type of Lewis acid catalytic [2+1+1] cycloaddition reactions of isocyanides with alkylidene malonates and 3‑alkylideneindolinones were reported herein. The method exhibited the easily accessible starting materials, broad substrate... Click to show full abstract

A new type of Lewis acid catalytic [2+1+1] cycloaddition reactions of isocyanides with alkylidene malonates and 3‑alkylideneindolinones were reported herein. The method exhibited the easily accessible starting materials, broad substrate...

Keywords: syntheses highly; cyclobutenes via; functionalized cyclobutenes; highly functionalized; via cycloaddition; cycloaddition

Journal Title: Organic Chemistry Frontiers
Year Published: 2024

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