Herein, we present a redox-relay strategy that enables the nickel-catalyzed, atom-economical coupling of isatins and allyl alcohols. This reaction is notable for its lack of requirement for additional ligands or… Click to show full abstract
Herein, we present a redox-relay strategy that enables the nickel-catalyzed, atom-economical coupling of isatins and allyl alcohols. This reaction is notable for its lack of requirement for additional ligands or reducing agents, and minimal catalyst usage (only 1%), thus meeting the principles of green chemistry. Mechanistic studies have shown that allyl alcohols act as both reductants and precursors for α,β-unsaturated ketones in the reaction.
Keywords:
relay strategy;
atom economical;
redox relay;
catalyzed atom;
nickel catalyzed;
allyl alcohols
Journal Title: Chemical communications
Year Published: 2025
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Journal Title: Chemical communications
Year Published: 2025
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!