G-quadruplexes (G4s) regulate multiple biological processes by interacting with G4-binding proteins (G4BPs). We developed a sandwich ELISA system to evaluate G4 ligand effects on G4-G4BP binding. G4 ligands strongly affect… Click to show full abstract
G-quadruplexes (G4s) regulate multiple biological processes by interacting with G4-binding proteins (G4BPs). We developed a sandwich ELISA system to evaluate G4 ligand effects on G4-G4BP binding. G4 ligands strongly affect G-quartet-protein interactions, demonstrating that high binding affinity of G4 ligands for G4s does not guarantee ternary complex formation with G4BPs.
Keywords:
ligands interaction;
interaction quadruplexes;
binding proteins;
evaluation effects;
quadruplexes binding;
effects ligands
Journal Title: Chemical communications
Year Published: 2025
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!
Journal Title: Chemical communications
Year Published: 2025
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!