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(4+3) annulation of enone-tethered indoles with α-alkylidene succinimides: access to seven-membered azepino[3,2,1-hi]indole scaffolds

A (4+3) annulation of indole-enones and alkylidene succinimides for diastereoselective synthesis of seven-membered azepino[3,2,1-hi]indole scaffolds with four contiguous chiral carbons is reported. Click to show full abstract

A (4+3) annulation of indole-enones and alkylidene succinimides for diastereoselective synthesis of seven-membered azepino[3,2,1-hi]indole scaffolds with four contiguous chiral carbons is reported.

Keywords: azepino indole; seven membered; alkylidene succinimides; indole scaffolds; annulation enone; membered azepino

Journal Title: Chemical Communications
Year Published: 2025

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