We report a Co/Salox-catalyzed atroposelective C-H activation/annulation process that concurrently constructs dual C-N stereogenic axes under mild conditions. By incorporating acyclic axial chirality into 1,3-biaxial scaffolds, we achieve diverse multi-axial… Click to show full abstract
We report a Co/Salox-catalyzed atroposelective C-H activation/annulation process that concurrently constructs dual C-N stereogenic axes under mild conditions. By incorporating acyclic axial chirality into 1,3-biaxial scaffolds, we achieve diverse multi-axial chiral architectures, thereby expanding the synthetic application of Co(II)/Salox catalytic systems.
Keywords:
atroposelective synthesis;
activation annulation;
synthesis isoquinolinone;
activation;
isoquinolinone bearing
Journal Title: Chemical communications
Year Published: 2025
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Journal Title: Chemical communications
Year Published: 2025
Link to full text (if available)
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recommendations!