We report a simple protocol for the transformation of Csp3–Csp3 to Csp3–N in homobenzylic sulfonamides in combination with N-iodoimides to form gem-diamino derivatives. The reaction exhibits a wide functional group… Click to show full abstract
We report a simple protocol for the transformation of Csp3–Csp3 to Csp3–N in homobenzylic sulfonamides in combination with N-iodoimides to form gem-diamino derivatives. The reaction exhibits a wide functional group tolerance and allows the incorporation of bioactive-derived fragments. The mechanistic insights provided by control experiments and DFT calculations suggest that an imine intermediate is formed after C–C bond cleavage.
Keywords:
light initiated;
homobenzylic sulfonamides;
visible light;
initiated metal;
csp3 csp3;
csp3
Journal Title: Chemical Science
Year Published: 2025
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Journal Title: Chemical Science
Year Published: 2025
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!