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Colorectal tumors have been classified based on histologic factors, genetic factors, and consensus molecular subtypes, which all affect the tumor microenvironment (TME). Elements of the TME serve as therapeutic targets… Click to show full abstract
Colorectal tumors have been classified based on histologic factors, genetic factors, and consensus molecular subtypes, which all affect the tumor microenvironment (TME). Elements of the TME serve as therapeutic targets and might be used as prognostic factors. For example, immune checkpoint inhibitors are used to treat tumors with microsatellite instability, and anti-angiogenic agents may be used in combination with other drugs to slow or inhibit tumor growth. We review the features of the colorectal tumor stroma that associate with outcomes of patients and discuss potential therapeutic agents that target these features.
Journal Title: Gastroenterology
Year Published: 2019
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