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Lactated Ringers vs. Normal Saline Resuscitation for Mild Acute Pancreatitis: A Randomized Trial.

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cute pancreatitis (AP) is a leading cause of hospiAtalization in the United States, resulting in significant morbidity and cost. In the absence of proven pharmacologic interventions, early aggressive intravenous hydration… Click to show full abstract

cute pancreatitis (AP) is a leading cause of hospiAtalization in the United States, resulting in significant morbidity and cost. In the absence of proven pharmacologic interventions, early aggressive intravenous hydration has been the mainstay of treatment; however, although clinical practice guidelines and expert opinion agree on fluid volume, equipoise remains regarding optimal type. It appears that pH-balanced Lactated Ringer’s (LR) solution is less likely to induce metabolic acidosis at large volumes compared with normal saline (NS) and results in supraphysiologic hyperchloremia, which may contribute to kidney injury. Nevertheless, smaller trials comparing fluid type have yielded conflicting results.

Keywords: saline resuscitation; pancreatitis; ringers normal; resuscitation mild; normal saline; lactated ringers

Journal Title: Gastroenterology
Year Published: 2020

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