LAUSR

Abstract Background This study was aimed to evaluate the effect of 0.0015% preservative-free tafluprost (Zioptan®) and 0.005% preservative containing latanoprost ophthalmic solutions (Lataprost®) on intraocular pressure (IOP) in healthy male guinea pigs (Cavia porcellus). Methods A total of 16 male guinea pigs were randomly assigned to receive one drop of tafluprost or one drop of latanoprost in the right eye. The contralateral eye served as control. IOP was measured using a rebound tonometer at time 0. at time 30 minutes and every 60 minutes for the next 3 hours and then every 3 hours for the next 21 hours. Results Administration of tafluprost and latanoprost was not associated with changes in IOP in the treated eyes. The maximum IOP-lowering effect of the ophthalmic solutions was observed 30 minutes post-instillation in the treated eyes (-1.25 ± 1.50 mmHg, P value = 0.194 in group A and -1.50 ± 1.29 mmHg, P value = 0.103 in group B) and returned to normal after 9 and 12 hours in group A and group B, respectively. There was no significant difference between the IOP measurements of the right and left eyes in neither animals during the study (repeated measure test and Generalized Linear Mixed Model). Conclusions and Clinical Relevance The administration of one drop of tafluprost and latanoprost had no significant effect on the IOP of healthy eyes in guinea pigs. Further studies in guinea pigs affected by glaucoma are needed to further explore the effectiveness of this drug.