Photo by homajob from unsplash
A method for dirhodium-catalyzed C(sp3)-H amidation of N,N-dimethylanilines was developed. Chemoselective C(sp3)-H amidation of N-methyl group proceeded exclusively in the presence of C(sp2)-H bonds of the electron-rich aromatic ring. Site-selective… Click to show full abstract
A method for dirhodium-catalyzed C(sp3)-H amidation of N,N-dimethylanilines was developed. Chemoselective C(sp3)-H amidation of N-methyl group proceeded exclusively in the presence of C(sp2)-H bonds of the electron-rich aromatic ring. Site-selective C(sp3)-H amidation proceeded exclusively at the N-methyl group of N-methyl-N-alkylaniline derivatives with secondary, tertiary, and benzylic C(sp3)-H bonds α to a nitrogen atom.
Keywords:
site selective;
sp3 amidation;
amidation;
dirhodium catalyzed
Journal Title: Synlett
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!
Journal Title: Synlett
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!