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The three-starting materials four-component reaction of (trifluoromethyl)alkenes, TBHP, and boronic acids is reported, delivering various useful α-trifluoromethyl-β-aryloxy tertiary alcohols in high yields and in an exclusively regioselective hydroetherification manner. TBHP… Click to show full abstract
The three-starting materials four-component reaction of (trifluoromethyl)alkenes, TBHP, and boronic acids is reported, delivering various useful α-trifluoromethyl-β-aryloxy tertiary alcohols in high yields and in an exclusively regioselective hydroetherification manner. TBHP serves as both the oxidant and nucleophile in this reaction, as well as the O-source of the products.
Keywords:
trifluoromethyl aryloxy;
trifluoromethyl alkenes;
tertiary alcohols;
trifluoromethyl;
boronic acids;
aryloxy tertiary
Journal Title: Synthesis
Year Published: 2021
Link to full text (if available)
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Journal Title: Synthesis
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!