We report a convenient method for the highly site selective borylation of 8-arylquinoline. The reaction proceeds smoothly in presence of catalytic amount of [Ir(OMe)(cod)]2 and 2-phenylpyridine derived ligand using bis(pinacolato)diborane… Click to show full abstract
We report a convenient method for the highly site selective borylation of 8-arylquinoline. The reaction proceeds smoothly in presence of catalytic amount of [Ir(OMe)(cod)]2 and 2-phenylpyridine derived ligand using bis(pinacolato)diborane as the borylating agent. The reactions occur with high selectivity with many functional groups, providing a series of borylated 8-aryl quinolines with good to excellent yield and excellent selectivity. The borylated compounds formed in this method can be transformed to various important synthons using known transformations.
Journal Title: Synthesis
Year Published: 2021
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