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A mild and facile synthetic method via convergent assembly of two reactive intermediates generated in situ has been developed. This method provides an efficient way to construct six- and seven-membered… Click to show full abstract
A mild and facile synthetic method via convergent assembly of two reactive intermediates generated in situ has been developed. This method provides an efficient way to construct six- and seven-membered N-heterocycles containing a biaryl linkage. This reaction features a gem-difunctionalization process of diazo compounds with cyclic hemiaminals, delivering α-hydroxyl-β-amino ester derivatives with a tertiary carbon center through a formal C–O bond-insertion transformation.
Keywords:
bond insertion;
insertion cyclic;
catalyzed formal;
formal bond
Journal Title: Synlett
Year Published: 2021
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Journal Title: Synlett
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!