An efficient synthetic route to citreochlorol analogs, halogenated polyketide secondary metabolites, is described. The key features are Krische's enantioselective carbonyl allylation, IBr-promoted cyclization, and regioselective epoxide opening. The importance of… Click to show full abstract
An efficient synthetic route to citreochlorol analogs, halogenated polyketide secondary metabolites, is described. The key features are Krische's enantioselective carbonyl allylation, IBr-promoted cyclization, and regioselective epoxide opening. The importance of the route lies in the access of the versatile epoxy ether 14, which opens access to the citreochlorol monochloro derivatives 5 and 6.
Keywords:
enantioselective carbonyl;
citreochlorol monochloro;
citreochlorol;
carbonyl allylation
Journal Title: Synthesis
Year Published: 2021
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Journal Title: Synthesis
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!