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‘Leukodystrophy-Like’ Phenotype in anti-MOG antibody-associated disorders

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). A 7-year-old girl developed sudden-onset right-faciobrachial hemiparesis after 3-month period of progressive abnormal behavior and academic impairment without encephalopathy. Brain MRI at diagnosis showed an extensive and confluent bilateral… Click to show full abstract

). A 7-year-old girl developed sudden-onset right-faciobrachial hemiparesis after 3-month period of progressive abnormal behavior and academic impairment without encephalopathy. Brain MRI at diagnosis showed an extensive and confluent bilateral white matter involvement and gadolinium enhancement (Figure 1). Metabolic and infectious studies were negative. The CSF profile showed mild pleocytosis and oligoclonal-bands were negative. Serum Autoantibodies against myelin-oligodendrocyte-glycoprotein (MOG-abs) were 1/1280 at onset. After early treatment with intravenous methylprednisolone and rituximab, her motor function fully recovered. After 12-month follow-up, mild

Keywords: leukodystrophy like; anti mog; mog antibody; phenotype anti; mog; like phenotype

Journal Title: Neuropediatrics
Year Published: 2022

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