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The mechanism of hyperoxia-induced neonatal renal injury and the possible protective effect of Resveratrol.

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With recent advances in neonatal intensive care, preterm infants are surviving into adulthood. Nonetheless,epidemiological data on the health status of these preterm infants has begun to reveal a worrying theme;… Click to show full abstract

With recent advances in neonatal intensive care, preterm infants are surviving into adulthood. Nonetheless,epidemiological data on the health status of these preterm infants has begun to reveal a worrying theme; prematurity and the supplemental oxygen therapy these infants receive after birth appear to be risk factors for kidney disease in in adulthood, affecting their quality-of-life. As the incidence of chronic kidney disease and the survival time of preterm infants both increase, the management of hyperoxia-induced renal disease is becoming increasingly relevant to neonatologists. The mechanism of this increased risk is currently unknown, but prematurity itself and the hyperoxia exposure after birth may predispose to disease by altering the normal trajectory of kidney maturation. This article reviews altered renal reactivity due to hyperoxia, the possible mechanisms of renal injury due to hyperoxia, and the role of resveratrol in renal injury.

Keywords: hyperoxia induced; renal injury; disease; mechanism; hyperoxia

Journal Title: American journal of perinatology
Year Published: 2022

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