LAUSR

Concomitant malignant gastric outlet and biliary obstruction is a morbid complication of pancreatic cancer [1]. Double endoscopic bypass with endoscopic ultrasound-guided gastroenterostomy (EUS-GE) and an EUS-guided choledochoduodenostomy or hepatogastrostomy is a promising but technically challenging modality in gastric outlet and biliary obstruction [2]. The advent of dedicated biliary lumen-apposing metal stents (LAMS) [3] has the potential to greatly facilitate double endoscopic bypass and enhance its adoptability [2]. An 80-year-old woman with stage IV pancreatic cancer presented with gastric outlet and biliary obstruction secondary to tumor progression. An endoscopic retrograde cholangiopancreatography was unsuccessful owing to the inability to reach the papilla. Following informed consent, we proceeded with a double endoscopic bypass (▶Video 1). A therapeutic gastroscope was advanced to the level of the obstruction in the duodenum. A 0.035-mmwire was inserted up to the jejunum followed by a 7-Fr nasobiliary drain to the ligament of Treitz (▶Fig. 1 a). Saline combined with contrast and methylene blue was injected into small bowel (400ml) (▶Fig. 1 b). The echoendoscope was then inserted and the distended small bowel located under endoscopic ultrasound (EUS). A 15×10-mm lumen-apposing metal stent (LAMS) (Axios; Boston Scientific, Marlborough, Massachusetts, USA) was then inserted directly using cautery assistance and deployed successfully forming the gastroenterostomy (▶Fig. 1 c). The echoendoscope was then advanced to the bulb of duodenum to locate the dilated common bile duct measuring 12.5mm in diameter (▶Fig. 2 a). A 6×8-mm biliary LAMS was then inserted using cautery assistance and deployed to establish the choledochoduodenostomy (▶Fig. 2b). The total procedure time was 36 minutes. The patient’s bilirubin decreased as expected E-Videos