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Kawasaki Disease Triggering an Episode of Psoriasis - a Case Report.

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Kawasaki disease (KD) is an acute systemic inflammatory illness causing vasculitis. A diffuse polymorphous rash is one of the predominant features of patients presenting with KD. This rash can have… Click to show full abstract

Kawasaki disease (KD) is an acute systemic inflammatory illness causing vasculitis. A diffuse polymorphous rash is one of the predominant features of patients presenting with KD. This rash can have a morbilliform, urticarial, micropustular, or further unspecific morphology. Psoriasis-like eruptions following KD were first described by Han et al. 2000 (Han M H et al., Br J Dermatol 2000; 142: 548–550), thereafter several case reports – describing over 30 children worldwide – have been published. It usually consists of a single episode with enduring remission, contrasting typical psoriasis. Furthermore, the eruptions can have an atypical presentation with less involvement of the anogenital area and more serous crusting (Haddock E S et al., J Am Acad Dermatol 2016; 75: 69–76), (Eberhard B A et al., J Pediatr 2000; 137, 4: 578–580). It is a well-known entity amongst dermatologists. However, acknowledgement by the paediatric community is limited. This is also mia (Hb 68 g/l) and an erythrocyte sedimentation rate (ESR) of 77 mm/1 h with normal platelets and no lymphopaenia. A nasopharyngeal aspirate PCR test was negative for respiratory viruses (including SARS-CoV-2). Serum SARS-CoV-2 IgG (anti-Nucleocapsid IgG and anti-Spike protein IgG) were negative. Echocardiography did not show any abnormalities. Fulfilling clinical criteria for complete KD, treatment with high-dose intravenous immunoglobulins (2 g/kg/dose) and high-dose oral acetyl salicylic acid (65 mg/kg/day) was initiated, and given his young age, intravenous methylprednisolone (2 mg/kg/day) was added. His clinical course was favourable and he defervesced within the first 24 hours after initiating KD treatment. On day 10 he was discharged on a weaning dose of oral prednisolone and low dose oral acetyl salicylic acid.

Keywords: dose oral; kawasaki disease; disease triggering; case; triggering episode; psoriasis

Journal Title: Klinische Padiatrie
Year Published: 2022

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