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Using electron-rich or electron-poor N-substituted oxazolidines as substrates, selective formation of either ammonium or oxonium ylides is possible in the presence of α-imino carbenes. As such, treatment of 5-membered oxazolidine… Click to show full abstract
Using electron-rich or electron-poor N-substituted oxazolidines as substrates, selective formation of either ammonium or oxonium ylides is possible in the presence of α-imino carbenes. As such, treatment of 5-membered oxazolidine precursors with N-sulfonyl-1,2,3-triazoles under dirhodium catalysis (2 mol%) affords the regiodivergent synthesis of either 8-membered 1,3,6- or 1,4,6-oxadiazocines upon the initial N- or O-reactivity with the carbene.
Keywords:
imino carbenes;
reactivity;
regiodivergent synthesis;
synthesis oxadiazocines
Journal Title: Synlett
Year Published: 2023
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Journal Title: Synlett
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!