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Electrochemical Cyclization of Hydrazones and Amidines To Access Trisubstituted 1,2,4-Triazoles

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KI-mediated electrochemical method for the synthesis of trisubstituted 1,2,4-triazoles from easily accessible hydrazones and amidines derivatives has been developed.The protocol provides various aryl and alkyl 1,2,4-triazoles in moderate to good… Click to show full abstract

KI-mediated electrochemical method for the synthesis of trisubstituted 1,2,4-triazoles from easily accessible hydrazones and amidines derivatives has been developed.The protocol provides various aryl and alkyl 1,2,4-triazoles in moderate to good yields, which achieves with good functional group tolerance and without the need for any chemical oxidants in an undivided cell.

Keywords: trisubstituted triazoles; cyclization hydrazones; hydrazones amidines; access trisubstituted; electrochemical cyclization; amidines access

Journal Title: Synlett
Year Published: 2023

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