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We developed a novel access to indoloindolone by a rhodium-catalyzed intramolecular acylation of 2-(indol-1-yl)benzoic acids. This reaction proceeds via the in situ formation of a mixed anhydride under redox-neutral reaction… Click to show full abstract
We developed a novel access to indoloindolone by a rhodium-catalyzed intramolecular acylation of 2-(indol-1-yl)benzoic acids. This reaction proceeds via the in situ formation of a mixed anhydride under redox-neutral reaction conditions. Preliminary mechanistic investigations revealed that the in situ-formed mixed anhydride participates in the C–H activation step, which is facilitated by a RhI catalyst. The utility of this reaction was demonstrated by a large-scale reaction.
Keywords:
catalyzed intramolecular;
indol benzoic;
intramolecular acylation;
rhodium catalyzed;
acylation indol;
benzoic acids
Journal Title: Synlett
Year Published: 2023
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Journal Title: Synlett
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!