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Chiral pentacarboxycyclopentadienyl bromide reagents were synthesized to accomplish enantioselective bromination of silyl enol ethers to give corresponding α-bromoketone products in good yields and up to 77% ee. A catalytic version… Click to show full abstract
Chiral pentacarboxycyclopentadienyl bromide reagents were synthesized to accomplish enantioselective bromination of silyl enol ethers to give corresponding α-bromoketone products in good yields and up to 77% ee. A catalytic version of this reaction was also demonstrated through the combination of Lewis acid activators and diethyl 2,2-dibromomalonate as stoichiometric achiral bromine source.
Keywords:
chiral pentacarboxycyclopentadienyl;
silyl enol;
pentacarboxycyclopentadienyl bromide;
enantioselective bromination;
enol ethers;
bromination silyl
Journal Title: Synlett
Year Published: 2023
Link to full text (if available)
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Journal Title: Synlett
Year Published: 2023
Link to full text (if available)
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recommendations!