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C5-Aryl/heteroaryl uracil-based compounds have attracted continuous interest because of their wide biological potential. In this review we outlined the primary synthetic methods used to prepare designated uracils, all of which… Click to show full abstract
C5-Aryl/heteroaryl uracil-based compounds have attracted continuous interest because of their wide biological potential. In this review we outlined the primary synthetic methods used to prepare designated uracils, all of which were often combined to synthesize target compounds with potential biological activities. Significance of each approach and its limitation were also summarized. 1 Introduction 2 Coupling of pre-functionalized uracils with (hetero)aryl reagents 3 Coupling of functionalized uracils with unactivated aromatic (hetero)cycles 4 Coupling of unactivated uracil/uridine with functionalized aromatic (hetero)cycles 5 Direct coupling of unactivated uracils with unactivated aromatic and heterocycles 6 Summary and Prospects
Journal Title: Synlett
Year Published: 2023
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