A Pd-catalyzed decarboxylative dearomatization reaction of of a heterocyclic substrate enables access to an uncommon reaction intermediate, that rearomatizes in the presence of amine bases in a net C–H functionalization… Click to show full abstract
A Pd-catalyzed decarboxylative dearomatization reaction of of a heterocyclic substrate enables access to an uncommon reaction intermediate, that rearomatizes in the presence of amine bases in a net C–H functionalization sequence. The dearomatized benzo[b]thiophene intermediate bears an exocyclic alkene that can be functionalized through cycloaddition and halogenation reactions to deliver complex heterocyclic products.
Keywords:
functionalization;
dearomatization;
palladium catalyzed;
benzothiophenes isolation;
catalyzed dearomatization;
dearomatization benzothiophenes
Journal Title: Synthesis
Year Published: 2023
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Journal Title: Synthesis
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!