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A nickel(II) chloride and tetrahydroxydiboron co-catalyzed facile synthesis of benzo[b]azepines appended a fluorinated sidechain

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A novel nickel-catalyzed chemoselective cascade reaction strategy towards the synthesis of benzo[b]azepine was developed. The method is characterized by simple and mild conditions, low cost, and a wide range of… Click to show full abstract

A novel nickel-catalyzed chemoselective cascade reaction strategy towards the synthesis of benzo[b]azepine was developed. The method is characterized by simple and mild conditions, low cost, and a wide range of substrates. The method enables the facile and efficient synthesis of a series of 2,3,4,5-tetrahydro-1H-benzo[b]azepine analogues appended a fluorinated sidechain.

Keywords: appended fluorinated; fluorinated sidechain; nickel chloride; synthesis; synthesis benzo

Journal Title: Synthesis
Year Published: 2023

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