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Visible light promoted click [3+2] cycloaddition of aziridine with alkyne: An efficient synthesis of dihydropyrrolidine

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A photocatalytic [3+2] cycloaddition of aziridines with activated alkynes is reported under visible light irradiation in the presence of ruthenium catalyst. This chemical transformation provides polysubstituted pyrrolidines in good yields… Click to show full abstract

A photocatalytic [3+2] cycloaddition of aziridines with activated alkynes is reported under visible light irradiation in the presence of ruthenium catalyst. This chemical transformation provides polysubstituted pyrrolidines in good yields based on the click chemistry philosophy. The reaction successfully represents a primary trial of cyclocarboamination through photocascade catalysis merging energy transfer and redox neutral reactions.

Keywords: click cycloaddition; cycloaddition aziridine; light promoted; promoted click; visible light; cycloaddition

Journal Title: Synlett
Year Published: 2023

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