LAUSR

Children with Duchenne Muscular Dystrophy (DMD) are at risk of experiencing fatigue that negatively impacts their health-related quality of life (HRQoL). This study aimed to assess the association between fatigue and HRQoL, by examining fatigue trajectories over 48 weeks, and assessing factors associated with these fatigue trajectories. The study sample consisted of 173 DMD subjects enrolled in a 48-week long phase 2 clinical trial (NCT00592553) for a novel therapeutic who were between the ages of 5 and 16 years. The results of regression modeling show baseline fatigue and baseline HRQoL (R2 = 0. 54 for child self-report and R2 = 0.51 for parent proxy) as well as change in fatigue and change in HRQoL over 48 weeks (R2 = 0.47 for child self-report and R2 = 0.36 for parent proxy-report) were significantly associated with one another. Three unique fatigue trajectories using Latent Class Growth Models were identified for child and parent proxy reported fatigue. The risk of being in the high fatigue group as compared to the low fatigue group increased by 24% with each year increase in age and also with decreasing walking distance, as reported by children and parent proxy, respectively. This study identified fatigue trajectories, and risk factors associated with greater fatigue, helping clinicians and researchers identify the profile of fatigue in DMD children.