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Here, we report an efficient higher order conjugate addition of azauracils to substituted para-Quinone methides (p-QMs) mediated by triethylamine to furnish hitherto unknown diarylmethane scaffolds through construction of a C-N… Click to show full abstract
Here, we report an efficient higher order conjugate addition of azauracils to substituted para-Quinone methides (p-QMs) mediated by triethylamine to furnish hitherto unknown diarylmethane scaffolds through construction of a C-N bond. The protocol features mild conditions, high atom economy, and broad scope, and enables convenient access to biologically relevant new chemical entities (NCEs) comprising p-QM and azauracil hybrid in good to excellent yields.
Keywords:
base promoted;
addition azauracils;
para quinone;
promoted aza;
quinone methides
Journal Title: Synthesis
Year Published: 2023
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Journal Title: Synthesis
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!