A dearomatization-guided and (3+2) cycloaddition-triggered annulation reaction of in situ formed isoquinolinium ylides with sulfamate-derived cyclic imines is reported, offering a cogent synthesis of tetracyclic 1,3-benzoxazepine frameworks in high yields.… Click to show full abstract
A dearomatization-guided and (3+2) cycloaddition-triggered annulation reaction of in situ formed isoquinolinium ylides with sulfamate-derived cyclic imines is reported, offering a cogent synthesis of tetracyclic 1,3-benzoxazepine frameworks in high yields. The protocol features successive ring-forming and ring-breaking events in a cascade fashion and is also scalable.
Keywords:
isoquinolinium ylides;
derived cyclic;
sulfamate derived;
benzoxazepine;
ylides sulfamate;
cyclic imines
Journal Title: Synthesis
Year Published: 2024
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Journal Title: Synthesis
Year Published: 2024
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!