A novel tandem reaction starting from alkynones and cyclic ketones has been developed to efficiently synthesize pyranoindolones fused with a medium-sized ring. This process involves a base-induced C–C σ-bond cleavage… Click to show full abstract
A novel tandem reaction starting from alkynones and cyclic ketones has been developed to efficiently synthesize pyranoindolones fused with a medium-sized ring. This process involves a base-induced C–C σ-bond cleavage reaction of cyclic ketone and subsequent I 2 -mediated 1,2-acyl migration/cyclization reaction. Transition-metal-free and easily accessible starting materials make this 1,2-acyl migration/cyclization methodology attractive.
Keywords:
reaction;
fused medium;
acyl migration;
migration cyclization
Journal Title: Synlett
Year Published: 2024
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Journal Title: Synlett
Year Published: 2024
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!