Alkenes are not only crucial feedstocks in the chemical industry but are also extensively present in natural products, pharmaceuticals, and organic functional materials. The direct difunctionalization of alkenes has emerged… Click to show full abstract
Alkenes are not only crucial feedstocks in the chemical industry but are also extensively present in natural products, pharmaceuticals, and organic functional materials. The direct difunctionalization of alkenes has emerged as a powerful and valuable strategy for the construction of highly functionalized organic skeletons. This short review highlights recent advancements in transition-metal-catalyzed remote 1,n-difunctionalization (n > 2) reactions of alkenes with the focus on innovative strategies involving chain-walking processes to construct complex, highly functionalized organic frameworks. 1 Introduction 2 Nickel Catalysis 3 Palladium Catalysis 4 Conclusion
Journal Title: Synthesis
Year Published: 2025
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